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Nobel Prize Laureate to Give Inspiration at NCKU

Michelle, Press Office
Oct. 15

Dr. Oliver Smithies, the Nobel Laureate in 2007, will be invited by the National Cheng Kung University (NCKU) to give a seminar on 18th October entitled “Turning Pages: From Gels to Genes” in the symposium with a theme on “The Gene Targeting in Embryonic Stem Cells and Its Effects on Biomedical Sciences”. The venue of this symposium is in the Cheng Hsing Hall at the NCKU College of Medicine.

The symposium will run from 9:00 a.m. to 5:30 p.m. on 18th October, starting with welcome remarks from the Academician and the NCKU President, Dr. Michael, M.C Lai, Professor Wei-Pin Lien, the President of the New Century Health Care Promotion Foundation which is the sponsor of this symposium, and Professor Chyi-Her Lin, the Dean of the NCKU College of Medicine.

Academician Michael, M.C. Lai, the NCKU president, especially attributed the success of this symposium to the support from the New Century Health Care Promotion Foundation, the Institute of Biomedical Science of Academia Sinica, the National Taiwan University College of Medicine, the NCKU College of Medicine, the NCKU Institute of Innovations and Advanced Studies, the Taiwan Society of Internal Medicine, Daiichi Sankyo Taiwan Ltd. Pfizer Taiwan Inc., and AstraZeneca PLC in Taiwan.

The Nobel Laureate lecture will focus on the Gene Knockout, which can be viewed as a new medical breakthrough for genetic science and engineering. Still, the techniques and researches on Gene Targeting play indispensable role on embryonic development, physiology and illness treatment. It is anticipated that all participants will have more in-depth discussion and knowledge about Gene Targeting technology during this symposium with the aim to enhance the medicinal and medical achievement in this field in Taiwan.

General public are all welcomed to attend this symposium. Refreshments will be served after the lecture, which is free and open to the general public.

Other presenters and topics of this symposium include Dr. Bon-Chu Chung on “Steroid Function and Regulation Revealed by Targeting Cypllal”, Dr. Shih-Hua Lin on “Gitelman and Gordon Syndrome: From Bedside to Knock-in Mice,” Dr. Nobuyo Maeda on “Genetic Variations in Atherosclerosis: Humans to Mice and Mice to Humans,” Dr. Patrick C.H. Hsieh on “The Application of Inducible Cre-Lox System for Cardiac Stem Cell Fate-Mapping,” Dr. Yau-Sheng Tsai on “Toll-Like Receptor in the Metabolic Disease and Its Complications,” Dr. Yu-Ting Yan on “Functional Study of the Small Heat Shock Protein HSPB7 in Heart Development,” Dr. Shu-Wha Lin on “Genetically Engineered Mouse Models for Thrombosis: Evaluation of the Thrombotic Activity of Factor IX with Augmented Clotting Function”.

About Dr. Oliver Smithies
Dr. Oliver Smithies, Excellence Professor of Pathology and Laboratory Medicine at the University of North Carolina (UNC) at Chapel Hill School of Medicine, is a co-recipient of 2007’s Nobel Prize in Medicine for his “Discoveries of Principles for Introducing Specific Gene Modification in Mice by Use of Embryonic Stem Cell”.

Born in 1928 in Yorkshire, England, Dr. Smithies as a young child was drawn to the idea of invention and enjoyed building telescopes and radios. He attended a high school for bright students and won a scholarship to Oxford University. He earned a Bachelor of Arts degree with a first-class honor in physiology from Oxford in 1946, and went on to earn his master’s degree and doctorate in biochemistry from Oxford in 1951.

In an interview with the Lasker Foundation, which honored him in 2001, Dr. Smithies credited his inspiration for science to a comic strip he read as a boy. The strip had an inventor and, Dr. Smithies said, that’s what he wanted to be and what he always has been.

He also said scientists should have three things in their lives: their work, a hobby and a family. Dr. Smithies is married to his UNC colleague Dr. Nobuyo Maeda, the Robert H. Wagner Distinguished Professor of Pathology and Laboratory Medicine. He also is a licensed airplane pilot and is especially fond of glider.

Dr. Smithies came to UNC in 1988 after his 28-year’s career at University of Wisconsin-Madison. In the mid-80s, while still at the University of Wisconsin at Madison, Dr. Smithies co-discovered a technique to introduce DNA material in cells, replicated a natural process called homologous DNA recombination. This method also enabled scientists to study specific genes by creating “knock-out mice.” His lab at UNC focused on developing animal models for studying gene therapy in hypertension and other genetic disorders, including sickle cell disease. He is a member of the UNC Lineberger Comprehensive Cancer Center.
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