NCKU research team reveals key mechanism in lung cancer - The China Post
TAIPEI, Taiwan -- A Tainan-based research team from National Cheng Kung University (NCKU) has discovered Rab37, a protein in humans that is a critical regulator of vesicle trafficking, which has played a vital role in the inhibition of cancer metastasis, according to a NCKU press release.
The team led by Yi-Ching Wang from the Department of Pharmacology and the Institute of Basic Medical Science, College of Medicine, made a major medical breakthrough in tumor treatment, the university revealed at a press conference in Taipei yesterday.
Their research, titled “Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumor metastasis,” has been published in the September issue of Nature Communications.
“What we've discovered will help clinicians to better treat patients with lung cancer,” said Wang.
She noted that Rab-controlled trafficking pathways have been involved in tumorigenesis.
Wang also explained that Rab37 suppresses metastasis by regulating the exocytosis of tissue inhibitors of metalloproteinase 1 (TIMP1) to repress matrix metalloproteinase 9 (MMP9) and represents a novel prognostic marker for lung cancer.
“We address the metastasis suppressive function of Rab37 using secretomics, cells, animal and clinical analyses,” Wang added.
The study shows that TIMP1is a novel cargo of Rab37, according to Wang, and lung cancer patients with metastasis show low Rab37 protein expression coinciding with low TIMP1 in tumors.
Wang's team has identified Rab37 as a novel metastasis suppressor Rab that functions through the TIMP1-MMP9 pathway and has significant prognostic power.
The team led by Yi-Ching Wang from the Department of Pharmacology and the Institute of Basic Medical Science, College of Medicine, made a major medical breakthrough in tumor treatment, the university revealed at a press conference in Taipei yesterday.
Their research, titled “Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumor metastasis,” has been published in the September issue of Nature Communications.
“What we've discovered will help clinicians to better treat patients with lung cancer,” said Wang.
She noted that Rab-controlled trafficking pathways have been involved in tumorigenesis.
Wang also explained that Rab37 suppresses metastasis by regulating the exocytosis of tissue inhibitors of metalloproteinase 1 (TIMP1) to repress matrix metalloproteinase 9 (MMP9) and represents a novel prognostic marker for lung cancer.
“We address the metastasis suppressive function of Rab37 using secretomics, cells, animal and clinical analyses,” Wang added.
The study shows that TIMP1is a novel cargo of Rab37, according to Wang, and lung cancer patients with metastasis show low Rab37 protein expression coinciding with low TIMP1 in tumors.
Wang's team has identified Rab37 as a novel metastasis suppressor Rab that functions through the TIMP1-MMP9 pathway and has significant prognostic power.
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