NCKU reveals novel noninvasive optical method for skin test
Tainan, Taiwan, Jan 8, 2013
Dr. Sheng-Hao Tseng from Department of Photonics at National Cheng Kung University (NCKU), southern Taiwan, has developed an optical system to quantify the properties of biological tissues noninvasively, assisting clinical treatment with more efficient and accurate diagnosis..
The system Dr. Tseng invented can be used to quantify the superficial skin absorption and scattering spectrum over a range of wavelength from 600mm to 1000mm.
Dr. Tseng said, “It can be applied to detect the concentration of hemoglobin, melanin, collagen and water of the skin and the condition of melanoma and skin aging, helping the doctors diagnose and treat the patients faster and more accurately.”
Using optical methods to non-invasively quantify the properties of biological tissues has gained great attention in recent years, according to Dr. Tseng who added that optical properties of tissues contain very useful information regarding the biological condition and the morphological status of tissues.
Thus, optical properties of tissues have been used for many diagnostic and therapeutic applications, such as cancer diagnosis, chemotherapy monitoring, photothermolysis, and photodynamic therapy.
Among many techniques used to determine the optical properties of biological tissues, diffuse reflectance spectroscopy (DRS) has been successfully employed to determine the absorption and scattering properties of deep tissues such as breast tumor, brain, and muscle, according to Tseng.
Dr. Tseng’s team has collaborated with the department of dermatology at NCKU to utilize the database to design the “modified two layer” probes to work with the DRS system for skin diagnostic and therapeutic applications.
The diffusing probe with “modified two layer geometry” is a novel design by the Tseng’s team. Compared to the conventional measurement geometry, the “modified two layer geometry” can be more efficient and accurate in recovering the optical properties of superficial tissues, according to Dr. Tseng.
Dr. Tseng whose research interests are mainly on Biomedical Tissue Optics, Skin Optics and Biomedical Optics Systems has worked with his colleges and recently published their new findings, “Noninvasive evaluation of collagen and hemoglobin contents and scattering property of in vivo keloid scars and normal skin using diffuse reflectance spectroscopy: pilot study,” on Journal of Biomedical Optics.
The collagen concentration, the hemoglobin oxygen saturation, and the reduced scattering coefficient of keloids are remarkably different from that of normal skin, revealed in the study.
Additionally, the system is proved to be capable of assisting in understanding the functional and structural condition of keloid scars and the applicability of the system for other skin-collagen-related studies will be investigated further, noted Dr. Tseng.
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Dr. Sheng-Hao Tseng from Department of Photonics at National Cheng Kung University (NCKU), southern Taiwan, has developed an optical system to quantify the properties of biological tissues noninvasively, assisting clinical treatment with more efficient and accurate diagnosis..
The system Dr. Tseng invented can be used to quantify the superficial skin absorption and scattering spectrum over a range of wavelength from 600mm to 1000mm.
Dr. Tseng said, “It can be applied to detect the concentration of hemoglobin, melanin, collagen and water of the skin and the condition of melanoma and skin aging, helping the doctors diagnose and treat the patients faster and more accurately.”
Using optical methods to non-invasively quantify the properties of biological tissues has gained great attention in recent years, according to Dr. Tseng who added that optical properties of tissues contain very useful information regarding the biological condition and the morphological status of tissues.
Thus, optical properties of tissues have been used for many diagnostic and therapeutic applications, such as cancer diagnosis, chemotherapy monitoring, photothermolysis, and photodynamic therapy.
Among many techniques used to determine the optical properties of biological tissues, diffuse reflectance spectroscopy (DRS) has been successfully employed to determine the absorption and scattering properties of deep tissues such as breast tumor, brain, and muscle, according to Tseng.
Dr. Tseng’s team has collaborated with the department of dermatology at NCKU to utilize the database to design the “modified two layer” probes to work with the DRS system for skin diagnostic and therapeutic applications.
The diffusing probe with “modified two layer geometry” is a novel design by the Tseng’s team. Compared to the conventional measurement geometry, the “modified two layer geometry” can be more efficient and accurate in recovering the optical properties of superficial tissues, according to Dr. Tseng.
Dr. Tseng whose research interests are mainly on Biomedical Tissue Optics, Skin Optics and Biomedical Optics Systems has worked with his colleges and recently published their new findings, “Noninvasive evaluation of collagen and hemoglobin contents and scattering property of in vivo keloid scars and normal skin using diffuse reflectance spectroscopy: pilot study,” on Journal of Biomedical Optics.
The collagen concentration, the hemoglobin oxygen saturation, and the reduced scattering coefficient of keloids are remarkably different from that of normal skin, revealed in the study.
Additionally, the system is proved to be capable of assisting in understanding the functional and structural condition of keloid scars and the applicability of the system for other skin-collagen-related studies will be investigated further, noted Dr. Tseng.
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